Recently, a team of scientists working for RhinoCyte™ Inc., of Louisville, Kentucky, conducted a new study on the effectiveness of using nasal stem cell treatment to repair damage to the spinal cord caused by contusions. The study, which was featured in the Journal of Neurodegeneration and Regeneration, was led by Dr. Fred Roisen.
This type of stem cell treatment may have a major impact on the lives of many people who are suffering from spinal injuries. Spinal contusions, or bruising, as it is more commonly known, can result from major trauma, such as that endured in an automobile accident, after a fall or during military combat. Approximately five million people around the world suffer from some type of spinal cord injury. More than twenty-five percent of those people are here in America, where treatment costs exceed forty billion dollars every year.
Currently, treatment options for spinal cord injuries are limited to rehabilitation and retention of mobility. Drug therapies are not available for these patients. However, stem cell research has shown great promise for treating this type of injury as well as a number of other types of neurodegeneration.
Previously, this group made national news with an experiment they conducted on lab rats. The spinal cords of the rodents were partially cut at the neck, causing paralysis in one of the front feet. After the rats were injected with nasal stem cells, significant use of the limb was regained.
The stem cells used in the study were derived from the olfactory neurosensory epithelium, which is the part of the nose that is responsible for the sense of smell. The cells were taken from adults already scheduled to undergo some form of elective sinus surgery who volunteered to be donors.
The stem cell extraction process did not affect the donor’s sense of smell in any way. In addition, the surgery is minimally invasive and is usually done as an outpatient service.
The stem cells were isolated and an enriched solution was added to increase the number of cells. Then the stem cells were injected into several of the lab rats. Within only twelve weeks, the test subjects had regained control of the affected foot. The control group, which was not given the stem cell treatment, did not experience the same positive results.
After additional testing showed continuously promising results, Dr. Roisen said, “This is very exciting on numerous levels.” Because the patient plays the role of both recipient and donor, there is no time spent waiting for a suitable donor and the need for immunosuppressive drugs is eliminated. Dr. Roisen also said, “And just as importantly, stem cells taken from the nose of an adult do away with the ethical concerns associated with using embryonic stem cells.”



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